Beta 2-adrenergic mechanisms in experimental arthritis.
نویسندگان
چکیده
منابع مشابه
Beta-2 adrenergic receptor
The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that interacts with (binds) epinephrine, a hormone and neurotransmitter (ligand synonym, adrenaline) whose signaling, via a downstream Ltype calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. Unlike other adr...
متن کاملMechanisms for myocardial beta-adrenergic receptor desensitization in heart failure.
C ongestive heart failure is associated with pronounced alterations in adrenergic nervous system function. Levels of myocardial norepinephrine are decreased, as first reported in 1963,1 a phenomenon later found to be associated with increased sympathetic nervous system activation and high levels of circulating plasma catecholamines2 in combination with abnormalities in neural reuptake of norepi...
متن کاملBeta-adrenergic blockade reduces myocardial injury during experimental cardiopulmonary resuscitation.
OBJECTIVES We attempted to determine the effects of beta-adrenergic blockade during cardiopulmonary resuscitation (CPR) on defibrillation rates and postresuscitation left ventricular function. BACKGROUND The results of previous studies suggest that propranolol administration can both reduce myocardial oxygen requirements and increase coronary perfusion pressure during CPR. METHODS Left vent...
متن کاملBeta 2-adrenergic responsiveness in vivo during abdominal surgery.
We have studied adrenergic function in vivo during anaesthesia and surgery. Epinephrine 50 ng kg-1 min-1 was given by i.v. infusion over 30 min to 10 healthy adult volunteers and to 10 patients undergoing abdominal operations. The cAMP response to stimulation by epinephrine, which was obtained as the area under the curve (AUC) for plasma cAMP concentration divided by the AUC for plasma concentr...
متن کاملIdentification of a beta 2-adrenergic receptor in mammalian epidermis.
The presence of a betaz-adrenergic receptor in the epidermis has been demonstrated, based on the following pieces of information: (I) the addition of salbutamol, a betas-agonist, to slices of epidermal tissue increased the levels of cyclic AMP in the tissue above control levels in a dose-dependent manner with a maximum response after 5 min of incubation in 5 x lo-’ M salbutamol, (2) the additio...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1988
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.85.12.4553